06-P050 Wnt antagonists regulate urethra tubercularization and cloaca septation
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06-P050 Wnt antagonists regulate urethra tubercularization and cloaca septation
Oesophageal atresia/Tracheo-oesophageal fistula (OA/TOF) are common congenital malformations of the foregut in newborns. Until recently little was known about the pathogenesis of these anomalies. Adriamycin, a chemotherapy agent, has been found to cause birth defects in mice that resemble the OA/TOF anomalies providing an animal model to study the etiology of the defects. A number of genes have...
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The extracellular antagonists of the Wnt signalling pathway can be divided into two broad classes. Both classes of molecule prevent ligand-receptor interactions, but by different mechanisms: members of the first class, which include the sFRP (secreted Frizzled-related protein) family, WIF (Wnt inhibitory factor)-1 and Cerberus, primarily bind to Wnt proteins; the second class comprises certain ...
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The primary mouth forms from ectoderm and endoderm at the extreme anterior of the embryo, a conserved mesoderm-free region. In Xenopus, a very early step in primary mouth formation is loss of the basement membrane between the ectoderm and endoderm. In an unbiased microarray screen, we defined genes encoding the sFRPs Frzb-1 and Crescent as transiently and locally expressed in the primary mouth ...
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tian and Moon, 1993) outside the organizer (Figure 1). Julia A. Yang-Snyder,* and Jeffrey R. Miller* Both specialists and nonspecialists examining these *Howard Hughes Medical Institute patterns of gene expression can appreciate Spemann’s and Department of Pharmacology image of interlocking fragments, and appreciate why †Molecular and Cellular Biology Program dissecting the workings of the gast...
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The present study was designed to investigate the relationship among epigenetic changes in Wnt antagonists, histone H4K20me1 and the expression of tumor-suppressor genes in acute leukemia (AL) to better understand the pathogenesis of leukemia. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to detect messenger RNA (mRNA) expression levels of Wnt antagonists ...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.276